Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.46 |
| ▸ | ITGAV | P06756 | 10/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 5/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FABP1 | P07148 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844128 | 0.92 | ITGB3 (0.52) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL12225870 | 0.85 | HTT (0.47) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL12225577 | 0.82 | NPC1 (0.58) | GAANPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL5844064 | 0.79 | ITGAV (0.72) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL5844569 | 0.79 | ITGAV (0.72) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL5844740 | 0.79 | ITGAV (0.72) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL5843713 | 0.79 | KMT2A (0.45) | ITGB3ITGAVNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5845136 | 0.79 | ITGB3 (0.55) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| SCHEMBL5846040 | 0.78 | ITGB3 (0.60) | ITGB3ITGAVITGB1ITGB6ITGB5 | |
| Hydrochloric Acid SCHEMBL360682 | 0.77 | GAA (0.56) | ITGB3ITGAVCYP1A2FABP1FABP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135587-B2 | Urea and urethane derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2006-11-14 | — | — | US | disclosed |
| EP-1343764-B1 | UREA AND URETHANE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2004-08-25 | — | — | EP | disclosed |
| US-20040063644-A1 | Urea and urethane derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
| EP-1343764-A1 | UREA AND URETHANE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GmbH (DE) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002050039-A1 | UREA AND URETHANE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063644-A1 | Urea and urethane derivatives as integrin inhibitors | ITGB1, ITGB2, ITGA1 | ITGB3 7/4885ITGAV 16/4885ITGB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.