Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845247 | 0.90 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL5845032 | 0.88 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL16606728 | 0.84 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL5843858 | 0.82 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5842891 | 0.81 | CRHR1 (0.44) | CRHR1 | |
| SCHEMBL5844155 | 0.81 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL5843759 | 0.81 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL5845373 | 0.80 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL16606729 | 0.77 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5843106 | 0.76 | CRHR1 (0.52) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125880-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-7067664-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-6956047-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050032846-A1 | Corticotropin releasing factor antagonists | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| EP-0832067-B1 | PROCESS FOR CONVERTING 2,4-DICHLOROPYRIDINES INTO 2-ARYLOXY-4-CHLOROPYRIDINES | PFIZER (US) | 2003-07-02 | — | — | EP | disclosed |
| US-6316631-B1 | REACTING 2,4-DICHLORO-3,6-DIALKYLPYRIDINE WITH PHENOL DERIVATIVE IN PRESENCE OF BASE AND COPPER CHLORIDE OR COPPER IODIDE OR COPPER BROMIDE TO FORM 2-ARYLOXY-4-CHLOROPYRIDINE COMPOUND, SALT FOMATION | PFIZER INC. | 2001-11-13 | — | — | US | disclosed |
| EP-0764166-B1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER (US) | 2000-09-13 | — | — | EP | disclosed |
| US-6043260-A | Method of treating heart failure | PFIZER INC (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0951906-A1 | Use of 3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-pyridines for treating heart failure | Pfizer Products Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5962479-A | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 1999-10-05 | — | — | US | disclosed |
| EP-0832067-A1 | PROCESS FOR CONVERTING 2,4-DICHLOROPYRIDINES INTO 2-ARYLOXY-4-CHLOROPYRIDINES | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0764166-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER INC. (US) | 1997-03-26 | — | — | EP | disclosed |
| WO-1996039388-A1 | PROCESS FOR CONVERTING 2,4-DICHLOROPYRIDINES INTO 2-ARYLOXY-4-CHLOROPYRIDINES | PFIZER INC. (US) | 1996-12-12 | — | — | WO | disclosed |
| WO-1995033750-A1 | CORTICOTROPIN RELEASING FACTOR ANTAGONISTS | PFIZER INC. (US) | 1995-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032846-A1 | Corticotropin releasing factor antagonists | CRH, CRHR2, CRHR1 | CRHR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.