Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | DDX3X | O00571 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28177397 | 0.88 | ALDH1A1 (0.55) | ALDH1A1HPGDALOX12SMN1; SMN2MAPT | |
| SCHEMBL14155070 | 0.81 | KMT2A (0.51) | ALDH1A1HPGDALOX12SMN1; SMN2MAPT | |
| SCHEMBL924103 | 0.79 | SMN1; SMN2 (0.63) | ALDH1A1HPGDALOX12SMN1; SMN2MAPT | |
| Dinitrophenylene SCHEMBL27481643 | 0.77 | TSHR (0.63) | ALDH1A1HPGDALOX12MAPTKMT2A | |
| SCHEMBL5880840 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HPGDALOX12SMN1; SMN2MAPT | |
| SCHEMBL730213 | 0.76 | MAPT (0.62) | ALDH1A1HPGDALOX12SMN1; SMN2MAPT | |
| SCHEMBL4186398 | 0.75 | HTT (0.62) | ALDH1A1SMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL2010242 | 0.74 | MAPT (0.56) | ALDH1A1HPGDALOX12SMN1; SMN2MAPT | |
| SCHEMBL28826075 | 0.74 | ALDH1A1 (0.54) | ALDH1A1HPGDALOX12SMN1; SMN2MAPT | |
| SCHEMBL27728555 | 0.74 | MAPT (0.50) | ALDH1A1HPGDMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3248594-A1 | TABLET FOR MULTIPLE ORAL APPLICATIONS | ratiopharm GmbH (DE) | 2017-11-29 | — | — | EP | disclosed |
| EP-2515852-B1 | FUSION TABLET CONTAINING COMPACTED SILDENAFIL BASE | RATIOPHARM GMBH (DE) | 2016-03-02 | — | — | EP | disclosed |
| US-8933081-B2 | Melting tablet containing a sildenafil salt | RATIOPHARM GMBH (DE) | 2015-01-13 | — | — | US | disclosed |
| EP-2416755-B1 | MELTING TABLET CONTAINING A SILDENAFIL SALT | RATIOPHARM GMBH (DE) | 2013-03-27 | — | — | EP | disclosed |
| EP-2515852-A1 | ORODISPERSIBLE TABLET CONTAINED COMPACTED SILDENAFIL BASE | Ratiopharm GmbH (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2512440-A1 | ORODISPERSIBLE TABLET, CONTAINING DAPOXETINE | Ratiopharm GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| US-20120071488-A1 | MELTING TABLET CONTAINING A SILDENAFIL SALT | RATIOPHARM GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| EP-2429528-A2 | ORODISPERSIBLE TABLET CONTAINING A VARDENAFIL SALT | Ratiopharm GmbH (DE) | 2012-03-21 | — | — | EP | disclosed |
| EP-2416755-A1 | MELTING TABLET CONTAINING A SILDENAFIL SALT | Ratiopharm GmbH (DE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2011076411-A1 | ORODISPERSIBLE TABLET CONTAINED COMPACTED SILDENAFIL BASE | RATIOPHARM GMBH (DE) | 2011-06-30 | — | — | WO | disclosed |
| EP-2338474-A1 | Fusion tablet containing compacted sildenafil base | Ratiopharm GmbH (DE) | 2011-06-29 | — | — | EP | disclosed |
| WO-2011072839-A1 | ORODISPERSIBLE TABLET, CONTAINING DAPOXETINE | RATIOPHARM GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2010130393-A2 | ORODISPERSIBLE TABLET CONTAINING A VARDENAFIL SALT | RATIOPHARM GMBH (DE) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010115576-A1 | MELTING TABLET CONTAINING A SILDENAFIL SALT | RATIOPHARM GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071488-A1 | MELTING TABLET CONTAINING A SILDENAFIL SALT | PDE9A, SORD, TAS2R39 | ALDH1A1 477/4885HPGD 446/4885ALOX12 4654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.