Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.59 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.59 |
| ▸ | ALB | P02768 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 1/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10912397 | 0.88 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL8734620 | 0.86 | PTGS2 (0.62) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL11438957 | 0.86 | PTGS2 (0.62) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL5157269 | 0.84 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL2829730 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL16413957 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL6687476 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL2888908 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL7433388 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL16879772 | 0.79 | PTGS2 (0.54) | PTGS2PTGS1AKR1C3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117342938-A | Preparation method of ibuprofen | 常州大学 | 2024-01-05 | — | — | CN | claimed |
| CN-111787915-A | Improved stability product comprising a local anesthetic, a buffering agent and a glycosaminoglycan in a syringe | 尤里根制药股份有限公司 | 2020-10-16 | — | — | CN | claimed |
| CN-103565733-A | Ibuprofen sodium chloride injection preparation with pH of 6.0-6.5, and preparation method thereof | NANJING DIYI MEDICAL TECHNOLOGY CO LTD | 2014-02-12 | — | — | CN | claimed |
| CN-117342938-A | Preparation method of ibuprofen | 常州大学 | 2024-01-05 | — | — | CN | disclosed |
| CN-111787915-A | Improved stability product comprising a local anesthetic, a buffering agent and a glycosaminoglycan in a syringe | 尤里根制药股份有限公司 | 2020-10-16 | — | — | CN | disclosed |
| US-10343977-B2 | Tetrahydro-isohumulone derivatives, methods of making and using | KINDEX PHARMACEUTICALS, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| EP-2870133-B1 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING | KINDEX PHARMACEUTICALS INC (US) | 2019-02-13 | — | — | EP | disclosed |
| US-20180297934-A1 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING | KINDEX PHARMACEUTICALS, INC. | 2018-10-18 | — | — | US | disclosed |
| US-9828331-B2 | Tetrahydro-isohumulone derivatives, methods of making and using | KINDEX PHARMACEUTICALS, INC. (US) | 2017-11-28 | — | — | US | disclosed |
| EP-2870133-A2 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING | Kindex Pharmaceuticals, Inc. (US) | 2015-05-13 | — | — | EP | disclosed |
| US-20150119461-A1 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING | KINDEX PHARMACEUTICALS, INC. | 2015-04-30 | — | — | US | disclosed |
| CN-103565733-A | Ibuprofen sodium chloride injection preparation with pH of 6.0-6.5, and preparation method thereof | NANJING DIYI MEDICAL TECHNOLOGY CO LTD | 2014-02-12 | — | — | CN | disclosed |
| WO-2014011680-A2 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING | KONDA VEERA (US) | 2014-01-16 | — | — | WO | disclosed |
| US-7012138-B1 | Chiral polysaccharide esters, one of the methods for preparing them and their uses for obtaining optically enriched acids or for chiral chromatography | UNIVERSITE DE DROIT D'ECONOMIE ET DES SCIENCES D'AIZ-MARSEILLE (FR) | 2006-03-14 | — | — | US | disclosed |
| CN-1665492-A | Platform for transdermal formulations (ptf) | HOLDEN DEV LTD (VG) | 2005-09-07 | — | — | CN | disclosed |
| US-20050118241-A1 | Platform for transdermal formulations (ptf) | HOLDEN DEVELOPMENT LIMITED (VG) | 2005-06-02 | — | — | US | disclosed |
| EP-1515706-A2 | A PLATFORM FOR TRANSDERMAL FORMULATIONS (PTF) | Holden Development Limited (VG) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004002444-A2 | A PLATFORM FOR TRANSDERMAL FORMULATIONS (PTF) | HOLDEN DEVELOPMENT LIMITED (DE) | 2004-01-08 | — | — | WO | disclosed |
| US-5660851-A | COVALENT ATTACHMENTOF A CARBOXYLIC ACID-CONTAINING ACTIVE MATERIAL THROUGH ANHYDRIDE BONDS TO A POLYMER THAT CONTAINS PENDANT CARBOXYLIC ACID GROUPS; DRUG DELIVERY | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIV. OF JERUSALEM (IL) | 1997-08-26 | — | — | US | disclosed |
| WO-1996039095-A1 | OCULAR INSERTS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (US) | 1996-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180297934-A1 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING | PPARA, PPARG, PTGES | PTGS2 34/4885PTGS1 19/4885AKR1C3 1387/4885 |
| US-10343977-B2 | Tetrahydro-isohumulone derivatives, methods of making and using | PPARA, PPARG, PTGES | PTGS2 34/4885PTGS1 19/4885AKR1C3 1387/4885 |
| US-20150119461-A1 | TETRAHYDRO-ISOHUMULONE DERIVATIVES, METHODS OF MAKING AND USING | PPARA, PPARG, PTGES | PTGS2 34/4885PTGS1 19/4885AKR1C3 1387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.