Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.42 |
| ▸ | PDE1A | P54750 | 4/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859599 | 1.00 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CBRD4 | |
| SCHEMBL5884154 | 0.90 | PDE5A (0.50) | PDE5APDE1APDE1BPDE1CBRD4 | |
| SCHEMBL5884369 | 0.90 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1CBRD4 | |
| SCHEMBL5845215 | 0.89 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL5845892 | 0.89 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL5860664 | 0.89 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL5860660 | 0.89 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL5860641 | 0.89 | PDE5A (0.42) | PDE5APDE1APDE1BPDE1CHDAC1 | |
| SCHEMBL5845859 | 0.89 | PDE5A (0.44) | PDE5APDE1APDE1BPDE1CPOLB | |
| SCHEMBL5845866 | 0.89 | PDE5A (0.44) | PDE5APDE1APDE1BPDE1CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115602-B2 | Heterocycles 3 | BAYER AKTIENGESELLSCHAFT (DE) | 2006-10-03 | — | — | US | disclosed |
| US-7074790-B2 | 5-ethylimidarotriazones | BAYER HEALTHCARE AG (DE) | 2006-07-11 | — | — | US | disclosed |
| US-20060040942-A1 | 5-ethylimidarotriazones | BAYER HEALTHCARE AG (DE) | 2006-02-23 | — | — | US | disclosed |
| US-20050065153-A1 | Novel heterocycles 3 | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-24 | — | — | US | disclosed |
| EP-1506198-A1 | 5-ETHYLIMIDAROTRIAZONES | Bayer HealthCare AG (DE) | 2005-02-16 | — | — | EP | disclosed |
| EP-1399447-A1 | IMIDAZOTRIAZINONES DERIVATIVES AND THEIR USE AGAINST INFLAMMATORY PROCESSES AND/OR IMMUNE DISEASES | Bayer HealthCare AG (DE) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003097645-A1 | 5-ETHYLIMIDAROTRIAZONES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |
| US-20030139415-A1 | Novel heterocycles 3 | BAYER HEALTHCARE AKTIENGESELLSCHAFT (DE) | 2003-07-24 | — | — | US | disclosed |
| WO-2002098879-A1 | IMIDAZOTRIAZINONES DERIVATIVES AND THEIR USE AGAINST INFLAMMATORY PROCESSES AND/OR IMMUNE DISEASES | BAYER HEALTHCARE AG (DE) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139415-A1 | Novel heterocycles 3 | NFATC1, NOD2, NFKBIA | PDE5A 1993/4885PDE1A 3380/4885PDE1B 3869/4885 |
| US-20060040942-A1 | 5-ethylimidarotriazones | IL5, EPX, NFATC1 | PDE5A 378/4885PDE1A 834/4885PDE1B 1074/4885 |
| US-20050065153-A1 | Novel heterocycles 3 | NFATC1, NOD2, NFKBIA | PDE5A 1993/4885PDE1A 3380/4885PDE1B 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.