SCHEMBL5846046

SCHEMBL5846046

Fc1ccc(C2=CCN(CCCCn3nnc4ccccc43)CC2)cc1

nearest known ligand 0.55

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 5/20 0.55
PARP1 P09874 1/20 0.52
P2RX7 Q99572 1/20 0.49
HTR7 P34969 2/20 0.48
SLC9A1 P19634 5/20 0.48
HTR1A P08908 1/20 0.47
DRD2 P14416 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5846765 0.99 SIGMAR1 (0.54) SIGMAR1PARP1P2RX7HTR7SLC9A1
SCHEMBL5846280 0.81 SIGMAR1 (0.61) SIGMAR1PARP1HTR7HTR1ADRD2
SCHEMBL8010714 0.80 SIGMAR1 (0.72) SIGMAR1PARP1HTR7DRD2
Hydrochloric Acid SCHEMBL5847442 0.80 SIGMAR1 (0.60) SIGMAR1PARP1HTR7HTR1ADRD2
SCHEMBL5846929 0.80 SIGMAR1 (0.55) SIGMAR1PARP1P2RX7HTR7HTR1A
SCHEMBL5846198 0.80 SIGMAR1 (0.55) SIGMAR1PARP1P2RX7HTR7HTR1A
Hydrochloric Acid SCHEMBL5847007 0.79 SIGMAR1 (0.54) SIGMAR1PARP1P2RX7HTR7HTR1A
SCHEMBL5846512 0.78 PARP1 (0.53) SIGMAR1PARP1P2RX7HTR7HTR1A
SCHEMBL5846473 0.76 PARP1 (0.55) SIGMAR1PARP1HTR7HTR1ADRD2
SCHEMBL6160951 0.75 SIGMAR1 (0.54) SIGMAR1PARP1P2RX7HTR7HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39113-E1 Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain LABORATORIES DEL DR. ESTEVE, S.A. (ES) 2006-05-30 US claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6384055-B1 ANALGESICS LABORATORIOS DEL DR. ESTEVES, S.A. (ES) 2002-05-07 US claimed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
WO-1996004287-A1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1996-02-15 WO claimed