SCHEMBL6160951

SCHEMBL6160951

Fc1ccc(C2=CCN(CCCCn3ccc4ccccc43)CC2)cc1

nearest known ligand 0.61

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.54
CDK4 P11802 3/20 0.51
CCND1 P24385 3/20 0.51
PARP1 P09874 1/20 0.49
HTR1A P08908 1/20 0.48
HTR7 P34969 1/20 0.48
ABCB1 P08183 2/20 0.47
DRD2 P14416 1/20 0.47
P2RX7 Q99572 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6162196 0.90 CDK4 (0.56) SIGMAR1CDK4CCND1PARP1ABCB1
SCHEMBL8010714 0.82 SIGMAR1 (0.72) SIGMAR1PARP1HTR7DRD2
SCHEMBL5846198 0.80 SIGMAR1 (0.55) SIGMAR1PARP1HTR1AHTR7DRD2
SCHEMBL5846929 0.80 SIGMAR1 (0.55) SIGMAR1PARP1HTR1AHTR7DRD2
Hydrochloric Acid SCHEMBL5847007 0.79 SIGMAR1 (0.54) SIGMAR1PARP1HTR1AHTR7DRD2
SCHEMBL19944762 0.76 SIGMAR1 (0.64) SIGMAR1PARP1HTR1AHTR7DRD2
SCHEMBL11830521 0.76 SIGMAR1 (0.64) SIGMAR1PARP1HTR7DRD2
SCHEMBL5846280 0.76 SIGMAR1 (0.61) SIGMAR1PARP1HTR1AHTR7DRD2
SCHEMBL12124558 0.76 DRD2 (0.68) SIGMAR1CDK4CCND1ABCB1DRD2
SCHEMBL5846512 0.76 PARP1 (0.53) SIGMAR1PARP1HTR1AHTR7DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed