Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | PRSS12 | P56730 | 5/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | OGG1 | O15527 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4651922 | 0.84 | MAPT (0.78) | F10MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL16210507 | 0.81 | F10 (0.70) | F10MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL6590270 | 0.77 | F10 (1.00) | F10PRSS12 | |
| SCHEMBL2901773 | 0.76 | P2RX7 (0.50) | MAPTKDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2248037 | 0.75 | F10 (0.69) | F10MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL6592760 | 0.75 | F10 (0.83) | F10MAPTRXFP1PRSS12SMN1; SMN2 | |
| SCHEMBL5935569 | 0.75 | MAPT (0.79) | F10MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL12767889 | 0.74 | MAPT (1.00) | F10MAPTKDM4EALDH1A1RXFP1 | |
| SCHEMBL2053138 | 0.73 | LMNA (0.52) | KDM4EALDH1A1MAPK1MEN1POLB | |
| SCHEMBL16562253 | 0.72 | F10 (0.63) | F10MAPTKDM4ERXFP1PRSS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984645-B2 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-10 | — | — | US | disclosed |