Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847769 | 0.95 | HTR2A (0.50) | HTR2AHTR2CHTR2BUSP30TACR1 | |
| SCHEMBL5846925 | 0.94 | HTR2A (0.47) | HTR2AHTR2CHTR2BUSP30TACR1 | |
| SCHEMBL5849712 | 0.89 | USP30 (0.39) | USP30PRMT5WDR77CCR3GPR119 | |
| SCHEMBL5847795 | 0.88 | HTR2A (0.59) | HTR2AHTR2CHTR2BCCR3EPHX2 | |
| SCHEMBL5846989 | 0.88 | MEN1 (0.41) | USP30PRMT5WDR77CCR3GPR119 | |
| SCHEMBL5418222 | 0.87 | HTR2B (0.43) | HTR2AHTR2CHTR2BCCR3 | |
| SCHEMBL5847472 | 0.87 | HTR2A (0.49) | HTR2AHTR2CHTR2BUSP30TACR1 | |
| SCHEMBL5847848 | 0.86 | USP30 (0.50) | USP30PRMT5WDR77CCR3JAK2 | |
| SCHEMBL5847300 | 0.86 | HTR2A (0.49) | HTR2AHTR2CHTR2BUSP30EPHX2 | |
| SCHEMBL5849629 | 0.85 | HTR2A (0.53) | HTR2AHTR2CHTR2BUSP30GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | claimed |
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |