Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.50 |
| ▸ | HTR2C | P28335 | 6/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846925 | 0.97 | HTR2A (0.47) | HTR2AHTR2CHTR2BUSP30TACR1 | |
| SCHEMBL5847101 | 0.95 | HTR2A (0.44) | HTR2AHTR2CHTR2BUSP30TACR1 | |
| SCHEMBL5847589 | 0.90 | HTR2A (0.53) | HTR2AHTR2CHTR2BTACR1GPR119 | |
| SCHEMBL5849629 | 0.90 | HTR2A (0.53) | HTR2AHTR2CHTR2BUSP30GPR119 | |
| SCHEMBL5848217 | 0.89 | HTR2A (0.66) | HTR2AHTR2CHTR2BGPR119EPHX2 | |
| SCHEMBL5416044 | 0.89 | HTR2A (0.66) | HTR2AHTR2CHTR2BGPR119EPHX2 | |
| SCHEMBL5848901 | 0.88 | HTR2A (0.40) | HTR2AHTR2CHTR2BUSP30GPR119 | |
| SCHEMBL5412602 | 0.88 | HTR2A (0.50) | HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL5849172 | 0.88 | HTR2A (0.50) | HTR2AHTR2CHTR2BTACR1GPR119 | |
| SCHEMBL5848926 | 0.88 | HTR2A (0.50) | HTR2AHTR2CHTR2BGPR119NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |