Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | HTR2C | P28335 | 7/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 6/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849267 | 0.97 | HTR2A (0.39) | HTR2AHTR2CHTR2BDRD2KDM1A | |
| SCHEMBL5847291 | 0.89 | HTR2A (0.49) | HTR2AHTR2CHTR2BGPR119 | |
| SCHEMBL5848901 | 0.88 | HTR2A (0.40) | HTR2AHTR2CHTR2BDRD2GPR119 | |
| SCHEMBL5847635 | 0.87 | HTR2A (0.40) | HTR2AHTR2CHTR2BDRD2GPR119 | |
| SCHEMBL5410543 | 0.87 | HTR2A (0.42) | HTR2AHTR2CHTR2BDRD2CYP11B2 | |
| SCHEMBL5847769 | 0.87 | HTR2A (0.50) | HTR2AHTR2CHTR2BDRD2GPR119 | |
| SCHEMBL5847746 | 0.86 | HTR2A (0.47) | HTR2AHTR2CHTR2BGPR119 | |
| SCHEMBL5847225 | 0.86 | MEN1 (0.39) | HTR2AHTR2CHTR2BDRD2GPR119 | |
| SCHEMBL5847380 | 0.86 | HTR2A (0.38) | HTR2AHTR2CHTR2BDRD2GPR119 | |
| SCHEMBL5846999 | 0.85 | HTR2A (0.39) | HTR2AHTR2CHTR2BDRD2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |