Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847225 | 0.97 | MEN1 (0.39) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL5846989 | 0.95 | MEN1 (0.41) | MEN1KMT2AUSP30MAPTLMNA | |
| SCHEMBL5846999 | 0.93 | HTR2A (0.39) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL5847469 | 0.91 | STS (0.39) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL5848567 | 0.91 | HTR2C (0.41) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL5846950 | 0.91 | HTR2A (0.40) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL5848904 | 0.90 | STS (0.41) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL5847635 | 0.89 | HTR2A (0.40) | HTR2AHTR2CHTR2BNPC1RAB9A | |
| SCHEMBL5847769 | 0.88 | HTR2A (0.50) | HTR2AHTR2CHTR2BNPC1RAB9A | |
| SCHEMBL5847375 | 0.88 | CNR1 (0.40) | HTR2AHTR2CHTR2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |