Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10860608 | 0.77 | IDO1 (0.47) | ALDH1A1CYP3A4IDO1TDO2CYP2C9 | |
| SCHEMBL5847586 | 0.74 | TAAR1 (0.50) | CYP2C19ALDH1A1CYP3A4ALOX15IDO1 | |
| Iodide SCHEMBL25290234 | 0.73 | AOC3 (0.65) | CYP2C19ALDH1A1CYP2C9AOC3HTR2A | |
| SCHEMBL20970894 | 0.73 | HTR2A (0.49) | TAAR1HTR2A | |
| SCHEMBL29543232 | 0.73 | HTR2A (0.49) | TAAR1HTR2A | |
| SCHEMBL1471049 | 0.73 | IDO1 (0.42) | ALDH1A1IDO1TDO2HTTTAAR1 | |
| SCHEMBL6325 | 0.73 | CYP2C19 (0.44) | CYP2C19ALDH1A1CYP3A4ALOX15IDO1 | |
| SCHEMBL11111739 | 0.73 | IDO1 (0.42) | ALDH1A1IDO1TDO2HTTTAAR1 | |
| SCHEMBL29369499 | 0.73 | CYP2C19 (0.44) | CYP2C19ALDH1A1CYP3A4ALOX15IDO1 | |
| SCHEMBL20773755 | 0.72 | ALOX12 (0.37) | IDO1TDO2AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078567-B2 | Amination process | JOHNSTON JEFFREY N | 2006-07-18 | — | — | US | disclosed |
| US-20040082778-A1 | Amination process | JOHNSTON JEFFREY N (US) | 2004-04-29 | — | — | US | disclosed |
| US-6670479-B2 | An sp2 hybridized radical is reacted with an azomethine group to form pyrrolidine and indole compounds | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. | 2003-12-30 | — | — | US | disclosed |
| WO-2002072547-A1 | AMINATION PROCESS | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. (US) | 2002-09-19 | — | — | WO | disclosed |
| US-20020128490-A1 | Amination process | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. | 2002-09-12 | — | — | US | disclosed |
| WO-2002070439-A2 | AMINATION PROCESS | JOHNSTON, JEFFREY, N. | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082778-A1 | Amination process | IDO2, INMT, IDO1 | CYP2C19 1254/4885ALDH1A1 567/4885CYP3A4 122/4885 |
| US-20020128490-A1 | Amination process | IDO2, INMT, IDO1 | CYP2C19 1146/4885ALDH1A1 106/4885CYP3A4 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.