Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847519 | 0.90 | F2 (0.46) | F2F10LMNATSHRMEN1 | |
| SCHEMBL393911 | 0.87 | GABBR2 (0.58) | F2F10GABBR2GABBR1LMNA | |
| SCHEMBL16681778 | 0.86 | F2 (0.48) | F2F10GABBR2GABBR1LMNA | |
| SCHEMBL4408370 | 0.84 | F2 (0.52) | F2F10GABBR2GABBR1LMNA | |
| SCHEMBL5847966 | 0.83 | F10 (0.39) | F2F10LMNATSHRMEN1 | |
| Hydrochloric Acid SCHEMBL7137209 | 0.82 | GABBR2 (0.60) | F2F10GABBR2GABBR1LMNA | |
| SCHEMBL391563 | 0.81 | F2 (0.44) | F2F10GABBR2GABBR1LMNA | |
| SCHEMBL10908208 | 0.80 | ALDH1A1 (0.51) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL657923 | 0.79 | MAPT (0.46) | F2F10GABBR2GABBR1LMNA | |
| SCHEMBL1504155 | 0.78 | ALDH1A1 (0.44) | CYP3A4CYP1A2TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115596-B2 | Thiazole compounds as integrin receptor antagonists derivatives | PHARMACIA CORPORATION (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1572690-A1 | THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20050004189-A1 | Thiazole compounds as integrin receptor antagonists derivatives | PHARMACIA CORPORATION | 2005-01-06 | — | — | US | disclosed |
| WO-2004058760-A1 | THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004189-A1 | Thiazole compounds as integrin receptor antagonists derivatives | ITGA5, ITGB5, ITGAL | F2 2878/4885F10 1591/4885GABBR2 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.