Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989148 | 0.79 | LMNA (0.31) | KDM4E | |
| SCHEMBL17511885 | 0.64 | KDM4E (0.45) | KDM4EMAPTPDPK1TGFBR1IKBKE | |
| SCHEMBL994997 | 0.59 | — | — | |
| SCHEMBL4501192 | 0.58 | CLK1 (0.40) | KDM4EMAPT | |
| SCHEMBL29569185 | 0.58 | CYP3A4 (0.66) | KDM4EMAPTIKBKE | |
| SCHEMBL2409389 | 0.58 | CYP3A4 (0.66) | KDM4EMAPTIKBKE | |
| SCHEMBL23991 | 0.58 | MAPT (0.45) | KDM4EMAPTPDPK1TGFBR1IKBKE | |
| SCHEMBL13629319 | 0.57 | KDM4C (0.47) | KDM4EMAPTPDPK1TGFBR1IKBKE | |
| SCHEMBL5846905 | 0.56 | — | — | |
| SCHEMBL29568863 | 0.55 | CYP3A4 (0.66) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119094-B1 | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade | WARNER-LAMBERT COMPANY (US) | 2006-10-10 | — | — | US | disclosed |