Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5848261 | 0.79 | KDM4E (0.33) | KDM4E | |
| SCHEMBL169349 | 0.74 | KDM4E (0.37) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29903165 | 0.71 | TNF (0.40) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL376002 | 0.71 | TNF (0.40) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL28253511 | 0.70 | TNF (0.42) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6283675 | 0.70 | KDM4E (0.31) | KDM4E | |
| SCHEMBL28035043 | 0.65 | HTT (0.39) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9543262 | 0.65 | KDM4E (0.47) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4501192 | 0.62 | CLK1 (0.40) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL209255 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292579-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2003-03-19 | — | — | EP | claimed |
| WO-2001087854-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRAZINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |