Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847375 | 0.97 | CNR1 (0.40) | HTR2CHTR2AHTR2BCNR1CNR2 | |
| SCHEMBL5847234 | 0.95 | CNR1 (0.41) | CNR1CNR2GPR119PAK1FNTA | |
| SCHEMBL5846950 | 0.93 | HTR2A (0.40) | HTR2CHTR2AHTR2BCNR1CNR2 | |
| SCHEMBL5847676 | 0.91 | GPR119 (0.39) | HTR2CHTR2AHTR2BCNR1CNR2 | |
| SCHEMBL5848901 | 0.91 | HTR2A (0.40) | HTR2CHTR2AHTR2BCNR1CNR2 | |
| SCHEMBL5848017 | 0.90 | HTR2A (0.45) | HTR2CHTR2AHTR2BGPR119NPC1 | |
| SCHEMBL5848881 | 0.90 | GPR119 (0.40) | HTR2CCNR1CNR2GPR119PAK1 | |
| SCHEMBL5847308 | 0.90 | USP30 (0.41) | HTR2CHTR2AHTR2BCNR1CNR2 | |
| SCHEMBL5847743 | 0.89 | HTR2A (0.48) | HTR2CHTR2AHTR2BGPR119NPC1 | |
| SCHEMBL5847225 | 0.88 | MEN1 (0.39) | HTR2CHTR2AHTR2BCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |