Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31269819 | 0.88 | OPRL1 (0.49) | ADRB2KDM4EBCHEOPRL1 | |
| SCHEMBL31270070 | 0.88 | OPRL1 (0.49) | ADRB2KDM4EBCHEOPRL1 | |
| SCHEMBL31270062 | 0.87 | BCHE (0.44) | ADRB2KDM4EBCHEOPRL1 | |
| Hydrochloric Acid SCHEMBL31270074 | 0.86 | BCHE (0.46) | ADRB2KDM4EBCHEOPRL1 | |
| SCHEMBL31270198 | 0.85 | KDM4E (0.48) | ADRB2KDM4EBCHEOPRL1 | |
| SCHEMBL31269992 | 0.82 | ADRB3 (0.49) | ADRB2KDM4EBCHEOPRL1 | |
| SCHEMBL5848784 | 0.81 | ADRB2 (0.54) | ADRB2KDM4EBCHE | |
| SCHEMBL5848565 | 0.81 | ADRB2 (0.57) | ADRB2KDM4E | |
| Hydrochloric Acid SCHEMBL29375517 | 0.81 | ADRB2 (0.54) | ADRB2KDM4EBCHE | |
| SCHEMBL5850142 | 0.80 | ADRB2 (0.55) | ADRB2KDM4EBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112605-B2 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | Research Institute of Materia Medica Chinese Acadamy of Medical Sciences (CN) | 2006-09-26 | — | — | US | disclosed |
| US-20040029951-A1 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | RESEARCH INSTITUTE OF MATERIAL MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES; | 2004-02-12 | — | — | US | disclosed |
| CN-1134413-C | Sulfonyl-containing pyrrolidone compound and preparation method and pharmaceutical application thereof | 诺瓦提斯公司 | 2004-01-14 | — | — | CN | disclosed |
| CN-1318541-A | Sulfonyl-containing pyrrolidone compound and preparation method and pharmaceutical application thereof | INST OF PHARMACOLOGY CHINESE A (CN) | 2001-10-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029951-A1 | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof | PTGS1, PTGS2, PTGER1 | ADRB2 768/4885KDM4E 1122/4885BCHE 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.