Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.74 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.64 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7062128 | 0.87 | KDM4E (0.83) | ALDH1A1KDM4EP2RY12MAPTPOLB | |
| SCHEMBL7051943 | 0.87 | KDM4E (0.72) | ALDH1A1KDM4EP2RY12MAPTPOLB | |
| SCHEMBL5849230 | 0.86 | P2RY12 (0.78) | ALDH1A1KDM4EP2RY12MAPTPOLB | |
| SCHEMBL5849382 | 0.86 | P2RY12 (0.74) | ALDH1A1KDM4EP2RY12MAPTPOLB | |
| SCHEMBL5849667 | 0.86 | KDM4E (0.71) | ALDH1A1KDM4EP2RY12MAPTPOLB | |
| SCHEMBL5851065 | 0.85 | P2RY12 (0.83) | ALDH1A1KDM4EP2RY12MAPTLMNA | |
| SCHEMBL5849200 | 0.84 | P2RY12 (1.00) | ALDH1A1KDM4EP2RY12MAPTLMNA | |
| SCHEMBL5849386 | 0.84 | P2RY12 (0.74) | ALDH1A1KDM4EP2RY12MAPTPOLB | |
| SCHEMBL5850915 | 0.84 | P2RY12 (0.74) | ALDH1A1KDM4EP2RY12MAPTPOLB | |
| SCHEMBL5851612 | 0.84 | P2RY12 (0.71) | ALDH1A1KDM4EP2RY12MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115741-B2 | 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds | ALEXION PHARMACEUTICALS, INC. | 2006-10-03 | — | — | US | disclosed |
| US-20030153556-A1 | Piperazine and homopiperazine compounds | MILLENNIUM PHARMACEUTICALS, INC. | 2003-08-14 | — | — | US | disclosed |
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153556-A1 | Piperazine and homopiperazine compounds | HAMP, MPL, F2 | ALDH1A1 3346/4885KDM4E 2962/4885P2RY12 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.