Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5418263 | 0.89 | CCR3 (0.38) | PDE4BHTR2AHTR2CHTR2BCCR3 | |
| SCHEMBL5847114 | 0.85 | HTR2A (0.45) | GPR119HTR2AHTR2CHTR2BCCR3 | |
| SCHEMBL5847616 | 0.84 | HTR2A (0.46) | GPR119HTR2AHTR2CHTR2BCCR3 | |
| SCHEMBL5847917 | 0.84 | HTR2A (0.46) | GPR119PDE4BHTR2AHTR2CHTR2B | |
| SCHEMBL5849712 | 0.83 | USP30 (0.39) | GPR119CCR3PIK3CDUSP30 | |
| SCHEMBL5847910 | 0.82 | PIK3CD (0.49) | GPR119PDE4BCCR3PIK3CDPIK3CA | |
| SCHEMBL5848229 | 0.82 | NPC1 (0.40) | GPR119PDE4BHTR2AHTR2CHTR2B | |
| SCHEMBL5848059 | 0.82 | USP30 (0.44) | GPR119HTR2AHTR2CHTR2BUSP30 | |
| SCHEMBL5847872 | 0.81 | PDE4B (0.40) | GPR119PDE4BHTR2AHTR2CHTR2B | |
| SCHEMBL5847313 | 0.80 | HTR2A (0.51) | GPR119PDE4BHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | claimed |
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |