Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | P2RY12 | Q9H244 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849376 | 0.90 | KIT (0.52) | KITP2RY12ALDH1A1KDM4EMEN1 | |
| SCHEMBL5851682 | 0.85 | KIT (0.55) | KITP2RY12ALDH1A1KDM4EMEN1 | |
| SCHEMBL5848798 | 0.84 | KIT (0.57) | KITP2RY12ALDH1A1KDM4EMEN1 | |
| SCHEMBL5851315 | 0.84 | KIT (0.54) | KITP2RY12ALDH1A1KDM4EMEN1 | |
| SCHEMBL5850542 | 0.84 | KIT (0.54) | KITP2RY12ALDH1A1KDM4EMEN1 | |
| SCHEMBL7064496 | 0.83 | ALDH1A1 (0.52) | P2RY12ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL5849579 | 0.83 | KIT (0.53) | KITP2RY12ALDH1A1KDM4EMEN1 | |
| SCHEMBL5850552 | 0.82 | P2RY12 (0.68) | P2RY12ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL5851715 | 0.80 | MAPT (0.57) | KITP2RY12ALDH1A1KDM4EMEN1 | |
| SCHEMBL5849427 | 0.80 | P2RY12 (0.57) | KITP2RY12ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115741-B2 | 4-thieno[2,3-D]pyrimidin-4-YL piperazine compounds | ALEXION PHARMACEUTICALS, INC. | 2006-10-03 | — | — | US | disclosed |
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |