Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.54 |
| ▸ | ITGAV | P06756 | 2/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.54 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29521664 | 0.84 | POLB (0.75) | HPGDPOLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL81434 | 0.84 | POLB (0.75) | HPGDPOLBRAB9ANPC1ALDH1A1 | |
| Phosphine SCHEMBL30387635 | 0.82 | POLB (0.72) | HPGDPOLBRAB9ANPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27918048 | 0.82 | POLB (0.72) | HPGDPOLBRAB9ANPC1ALDH1A1 | |
| SCHEMBL7516248 | 0.81 | HPGD (1.00) | HPGDPOLBRAB9ANPC1ALDH1A1 | |
| Phenylacetic Acid SCHEMBL28136536 | 0.80 | AKR1B1 (0.77) | HPGDAKR1B1FFAR1ALDH1A1HSD17B10 | |
| SCHEMBL3485567 | 0.80 | ITGB1 (0.67) | HPGDPOLBRAB9ANPC1ITGB3 | |
| SCHEMBL29612679 | 0.80 | ITGB1 (0.67) | HPGDPOLBRAB9ANPC1ITGB3 | |
| SCHEMBL9849440 | 0.80 | HPGD (0.73) | HPGDPOLBRAB9ANPC1ITGB3 | |
| Phenylurea SCHEMBL5852221 | 0.80 | AKR1B1 (0.63) | AKR1B1FFAR1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060166866-A1 | Cell adhesion inhibitors | BIOGEN, INC., A MASSACHUSETTS CORPORATION | 2006-07-27 | — | — | US | disclosed |
| US-7001921-B1 | Cell adhesion inhibitors | BIOGEN IDEC MA INC. (US) | 2006-02-21 | — | — | US | disclosed |
| EP-1082302-B1 | A VLA-4 INHIBITOR: OMEPUPA-V | BIOGEN INC (US) | 2003-12-17 | — | — | EP | disclosed |
| US-6630512-B2 | Antiinflammatory agents; autoimmune disease | BIOGEN, INC. | 2003-10-07 | — | — | US | disclosed |
| US-6624152-B2 | Inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention relates to pharmaceutical formulations comprising these compounds and methods of using them for inflammatory and autoimmune diseases | BIOGEN, INC. | 2003-09-23 | — | — | US | disclosed |
| US-20030083267-A1 | Cell adhesion inhibitors | BIOGEN, INC., A MASSACHUSETTS CORPORATION | 2003-05-01 | — | — | US | disclosed |
| US-20030018016-A1 | Cell adhesion inhibitors | BIOGEN IDEC MA, INC. | 2003-01-23 | — | — | US | disclosed |
| US-6495525-B1 | N-((4-(((2-METHYLPHENYLAMINO)CARBONYL)AMINO)PHENYL)ACETYL)-L -PROLYL-3-METHYL)-BETA-ALANINE; VERY LATE ANTIGEN-4 CELL ADHESION INHIBITOR; INFLAMMATION AND IMMUNE REACTIONS | BIOGEN, INC. | 2002-12-17 | — | — | US | disclosed |
| EP-0805796-B1 | CELL ADHESION INHIBITORS | BIOGEN INC (US) | 2002-12-11 | — | — | EP | disclosed |
| US-6376538-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | BIOGEN, INC. | 2002-04-23 | — | — | US | disclosed |
| US-6306840-B1 | ANTISTICKING AGENTS OF OLIGOPEPTIDES | BIOGEN, INC. | 2001-10-23 | — | — | US | disclosed |
| EP-1142867-A2 | Cell adhesion inhibitors | BIOGEN, INC. (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1082302-A1 | A VLA-4 INHIBITOR: OMEPUPA-V | BIOGEN, INC. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999061421-A1 | A NOVEL VLA-4 INHIBITOR: oMePUPA-V | BIOGEN, INC. (US) | 1999-12-02 | — | — | WO | disclosed |
| EP-0805796-A1 | CELL ADHESION INHIBITORS | BIOGEN, INC. (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022966-A1 | CELL ADHESION INHIBITORS | BIOGEN, INC. (US) | 1996-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166866-A1 | Cell adhesion inhibitors | ICAM1, VCAM1, EPCAM | HPGD 1598/4885POLB 4750/4885RAB9A 1779/4885 |
| US-20030083267-A1 | Cell adhesion inhibitors | ICAM1, VCAM1, EPCAM | HPGD 1598/4885POLB 4750/4885RAB9A 1779/4885 |
| US-20030018016-A1 | Cell adhesion inhibitors | ICAM1, VCAM1, EPCAM | HPGD 1598/4885POLB 4750/4885RAB9A 1779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.