Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | C5 | P01031 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2111868 | 0.86 | APP (0.56) | APPPTGS2PTGS1MAPTMEN1 | |
| SCHEMBL135272 | 0.78 | APP (0.45) | APPPTGS2PTGS1MAPTMEN1 | |
| SCHEMBL1679174 | 0.78 | APP (0.53) | APPPTGS2PTGS1MAPTMEN1 | |
| SCHEMBL2392981 | 0.72 | PTGS1 (0.59) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL15641429 | 0.72 | PTGS1 (0.59) | APPPTGS2PTGS1MAPTMEN1 | |
| SCHEMBL29538369 | 0.72 | PTGS1 (0.59) | APPPTGS2PTGS1MAPTMEN1 | |
| SCHEMBL1917129 | 0.72 | PTGS1 (0.59) | APPPTGS2PTGS1MAPTMEN1 | |
| SCHEMBL23464566 | 0.71 | TSHR (0.32) | TSHR | |
| SCHEMBL598280 | 0.70 | PTGS2 (0.61) | APPPTGS2PTGS1MAPTMEN1 | |
| SCHEMBL1590331 | 0.70 | PTGS2 (0.61) | APPPTGS2PTGS1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963259-B1 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| EP-2305640-A2 | Substituted diphenyl-ethers, -amines, -sulfides and -methanes for the treatment of respiratory diseases | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |