Fructose

Fructose

SCHEMBL5852871

O=C(CO)[C@H](O)[C@@H](O)[C@H](O)CO.O=C[C@@H](O)[C@H](O)[C@H](O)CO

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.45
TSHR P16473 1/20 0.45
PDE4A P27815 1/20 0.41
LMNA P02545 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
TDP1 Q9NUW8 1/20 0.36
USP2 O75604 1/20 0.34
SLCO1B1 Q9Y6L6 1/20 0.34
AKR1B1 P15121 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fructose SCHEMBL27535426 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Fructose SCHEMBL4432524 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Fructose SCHEMBL6397124 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Tagatose SCHEMBL8749463 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Fructose SCHEMBL3945244 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Fructose SCHEMBL7256729 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Tagatose SCHEMBL8848540 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Fructose SCHEMBL22117547 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Fructose SCHEMBL22117548 1.00 CYP2C9 (0.45) CYP2C9TSHRPDE4ALMNAL3MBTL1
Fructose SCHEMBL8106542 0.98 CYP2C9 (0.44) CYP2C9TSHRPDE4ALMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9056116-B2 Liquid ganaxolone formulations and methods for the making and use thereof MARINUS PHARMACEUTICALS (US) 2015-06-16 US disclosed
US-20130287851-A1 LIQUID GANAXOLONE FORMULATIONS AND METHODS FOR THE MAKING AND USE THEREOF IMMEDICA PHARMA US INC. 2013-10-31 US disclosed
US-7153971-B2 Contacting a carbohydrate with an amine to produce amino tetrahydroxy carbohydrate, protecting two hydroxy groups of tetrahydroxy carbohydrate, forming hydroxy heterocyclic-spiro moiety by reacting with activated carbonate, oxidizing OH COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2006-12-26 US disclosed
EP-1317460-A4 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF UNIV COLORADO STATE RES FOUND (US) 2005-04-20 EP disclosed
EP-1071676-A4 KINETIC RESOLUTION OF OLEFINS UNIV COLORADO STATE RES FOUND (US) 2004-09-29 EP disclosed
US-20040039209-A1 Compounds containing oxazolidinone moiety and uses thereof NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2004-02-26 US disclosed
EP-1021426-B1 CATALYTIC ASYMMETRIC EPOXIDATION UNIV COLORADO STATE RES FOUND (US) 2003-09-17 EP disclosed
EP-1317460-A1 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2003-06-11 EP disclosed
US-6409769-B1 ASYMMETRIC EPOXIDATION OF THE STEREOISOMERS WITH AN OXIDIZING AGENT AND A CHIRAL KETONE PRODUCING AN EPOXIDE OF AT LEAST ONE STEREOISOMER AT A RELATIVELY HIGHER RATE THAN AN EPOXIDE OF ANOTHER STEREOISOMER OF THE COMPOUND. COLORADO STATE UNIVERSITY RESEARCH FOUNDATION 2002-06-25 US disclosed
WO-2002018391-A1 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2002-03-07 WO disclosed
US-6348608-B1 ADDING OXIDIZING AGENT TO REACTION SOLUTION COMPRISING CHIRAL CYCLIC ENANTIOMERICALLY ENRICHED KETONE AND OLEFIN UNDER CONDITIONS EFFECTIVE TO GENERATE ENANTIOMERICALLY ENRICHED EPOXIDE, SEPARATING EPOXIDE FROM REACTION SOLUTION COLORADO STATE UNIVERSITY RESEARCH FOUNDATION 2002-02-19 US disclosed
EP-1071676-A1 KINETIC RESOLUTION OF OLEFINS COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2001-01-31 EP disclosed
EP-1021426-A4 CATALYTIC ASYMMETRIC EPOXIDATION UNIV COLORADO STATE RES FOUND (US) 2000-07-26 EP disclosed
EP-1021426-A1 CATALYTIC ASYMMETRIC EPOXIDATION COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2000-07-26 EP disclosed
WO-1999052886-A1 KINETIC RESOLUTION OF OLEFINS COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1999-10-21 WO disclosed
WO-1998015544-A1 CATALYTIC ASYMMETRIC EPOXIDATION COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 1998-04-16 WO disclosed
EP-0758250-A1 TEXAPHYRIN SOLID-SUPPORTS AND DEVICES THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1997-02-19 EP disclosed
WO-1995029702-A1 TEXAPHYRIN SOLID-SUPPORTS AND DEVICES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1995-11-09 WO disclosed
WO-1994009003-A1 SAPPHYRIN DERIVATIVES, CONJUGATES AND POLYMERS THEREOF AND EXPANDED PORPHYRIN CHROMATOGRAPHIC SUPPORTS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1994-04-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040039209-A1 Compounds containing oxazolidinone moiety and uses thereof OXER1, OXA1L, AOX1 CYP2C9 110/4885TSHR 4087/4885PDE4A 3079/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.