Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7292022 | 0.82 | HTR2C (0.56) | HTR2CNPSR1NFKB1TSHRCYP2C9 | |
| SCHEMBL5851184 | 0.82 | GPR84 (0.62) | HTR2CNPSR1NFKB1TSHRCYP2C9 | |
| SCHEMBL5852981 | 0.80 | GPR84 (0.64) | HTR2CCYP2C9ALDH1A1SLC6A4HDAC3 | |
| SCHEMBL7289716 | 0.77 | NPSR1 (0.47) | HTR2CNPSR1NFKB1TSHRCYP2C9 | |
| SCHEMBL7289880 | 0.76 | NPSR1 (0.59) | HTR2CNPSR1NFKB1TSHRCYP2C9 | |
| SCHEMBL5851527 | 0.75 | GPR84 (0.66) | HTR2CCYP2C9ALDH1A1SLC6A4HDAC3 | |
| SCHEMBL27566639 | 0.73 | HTR1D (0.47) | HTR2CNPSR1NFKB1TSHRCYP2C9 | |
| SCHEMBL5853052 | 0.73 | HTR3E (0.43) | HTR2CNPSR1ALDH1A1LMNAGLA | |
| SCHEMBL6516528 | 0.73 | HTR2C (0.55) | HTR2CNPSR1NFKB1TSHRCYP2C9 | |
| SCHEMBL29414816 | 0.73 | HTR2C (0.55) | HTR2CNPSR1NFKB1TSHRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-09-21 | — | — | US | disclosed |
| US-7084166-B2 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHEE RIUNITE S.P.A. (IT) | 2006-08-01 | — | — | US | disclosed |
| US-20040053987-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-03-18 | — | — | US | disclosed |
| EP-1337511-A1 | BIS-HETEROCYCLIC COMPOUNDS WITH ANTITUMOUR AND CHEMOSENSITISING ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002036561-A1 | BIS-HETEROCYCLIC COMPOUNDS WITH ANTITUMOUR AND CHEMOSENSITISING ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | ABCC1, MCL1, DPYD | HTR2C 2487/4885NPSR1 877/4885NFKB1 381/4885 |
| US-20040053987-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | ABCC1, TOP1, CHEK1 | HTR2C 1917/4885NPSR1 1120/4885NFKB1 681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.