Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585644 | 0.88 | PTGDR2 (0.67) | PTGDR2 | |
| SCHEMBL1650769 | 0.81 | L3MBTL1 (0.42) | PTGDR2SMN1; SMN2CYP1A2CYP2C19MEN1 | |
| SCHEMBL1333486 | 0.78 | PTGDR2 (0.67) | PTGDR2ALDH1A1 | |
| SCHEMBL1332152 | 0.77 | PTGDR2 (0.55) | PTGDR2LRRK2 | |
| SCHEMBL1333570 | 0.76 | PTGDR2 (0.46) | PTGDR2CYP1A2CYP2C19LRRK2MEN1 | |
| SCHEMBL1333518 | 0.76 | TSHR (0.50) | PTGDR2SMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL3930692 | 0.76 | PTGDR2 (0.53) | PTGDR2LRRK2 | |
| SCHEMBL1332534 | 0.75 | PTGDR2 (0.70) | PTGDR2CYP2C19 | |
| SCHEMBL1333182 | 0.74 | PTGDR2 (0.63) | PTGDR2 | |
| SCHEMBL5983987 | 0.73 | PTGDR2 (0.52) | PTGDR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963259-B1 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | claimed |
| EP-1963259-B1 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| EP-1963259-B1 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |