SCHEMBL5854995

SCHEMBL5854995

C[SiH](C)[Hf](Cl)(Cl)(NC(=O)c1cccc(C(C)(C)C)c1)c1cccc2c1Cc1ccccc1-2

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 4/20 0.38
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
HDAC8 Q9BY41 5/20 0.36
HDAC6 Q9UBN7 2/20 0.36
NR1H4 Q96RI1 1/20 0.35
ACHE P22303 3/20 0.34
TP53 P04637 1/20 0.33
KCNK9 Q9NPC2 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
BRAF P15056 1/20 0.32
CTSL P07711 1/20 0.32
ALDH1A1 P00352 1/20 0.31
HDAC3 O15379 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5854687 0.90 MAPK14 (0.37) MAPK14NPC1RAB9AHDAC8HDAC6
SCHEMBL5853476 0.88 RAB9A (0.42) MAPK14NPC1RAB9AMEN1KMT2A
SCHEMBL5854142 0.87 SMN1; SMN2 (0.40) MAPK14NPC1RAB9AHDAC8HDAC6
SCHEMBL5855160 0.84 RAB9A (0.39) MAPK14NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL5853604 0.82 NPC1 (0.38) NPC1RAB9AMEN1KMT2A
SCHEMBL5855486 0.81 NPC1 (0.42) NPC1RAB9AMEN1KMT2ACTSL
SCHEMBL5853400 0.80 RAB9A (0.51) NPC1RAB9AALDH1A1
SCHEMBL5853683 0.79 RAB9A (0.41) NPC1RAB9AMEN1KMT2AALDH1A1
SCHEMBL5853187 0.79 RAB9A (0.39) NPC1RAB9AMEN1KMT2ASMN1; SMN2
SCHEMBL5853914 0.79 NPC1 (0.40) NPC1RAB9ATP53MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7037989-B2 Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-05-02 US disclosed
US-20040242814-A1 COPOLYMERS OF ETHYLENE AND/OR ALPHA-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS EXXONMOBIL CHEMICAL PATENTS INC. 2004-12-02 US disclosed