Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5855848 | 0.96 | HCAR2 (0.44) | HCAR2CYP2C19CYP2D6CYP3A4PPARG | |
| SCHEMBL9709425 | 0.84 | HCAR2 (0.58) | HCAR2CYP2C19NOS2PPARGPPARA | |
| SCHEMBL9860853 | 0.84 | HCAR2 (0.58) | HCAR2CYP2C19NOS2PPARGPPARA | |
| SCHEMBL9709424 | 0.84 | HCAR2 (0.58) | HCAR2CYP2C19NOS2PPARGPPARA | |
| SCHEMBL11127289 | 0.77 | CYP2C19 (0.37) | CYP2C19CYP2D6CYP3A4PPARGPPARA | |
| SCHEMBL2487162 | 0.77 | HCAR2 (0.59) | HCAR2CYP2C19CYP2D6ALDH1A1LMNA | |
| SCHEMBL3482642 | 0.77 | HCAR2 (0.64) | HCAR2CYP2C19CYP3A4NOS2ALDH1A1 | |
| SCHEMBL3482700 | 0.77 | HCAR2 (0.64) | HCAR2CYP2C19CYP3A4NOS2ALDH1A1 | |
| SCHEMBL27216283 | 0.77 | HCAR2 (0.64) | HCAR2CYP2C19CYP3A4NOS2ALDH1A1 | |
| SCHEMBL27741031 | 0.75 | MAPT (0.39) | CYP2C19CYP2D6CYP3A4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7038076-B2 | Fumarate derivative, method for producing the same | SHOWA DENKO K.K. (JP) | 2006-05-02 | — | — | US | disclosed |
| CN-1181040-C | Fumarate derivative and process for producing the same | 昭和电工株式会社 | 2004-12-22 | — | — | CN | disclosed |
| EP-1301461-A2 | FUMARATE DERIVATIVE, METHOD FOR PRODUCING THE SAME | Showa Denko K.K. (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-20030060563-A1 | Fumarate derivative, method for producing the same | SHOWA DENKO K.K. (JP) | 2003-03-27 | — | — | US | disclosed |
| CN-1386116-A | Fumarate derivative, method for producing the same | SHOWA DENKO KK (JP) | 2002-12-18 | — | — | CN | disclosed |
| WO-2002006206-A2 | FUMARATE DERIVATIVE, METHOD FOR PRODUCING THE SAME | SHOWA DENKO K.K. (JP) | 2002-01-24 | — | — | WO | disclosed |