Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5855322 | 1.00 | ALOX15 (0.34) | ALOX15ALDH1A1TSHRKMT2AKDM1A | |
| SCHEMBL108504 | 0.81 | KDM1A (0.39) | ALOX15ALDH1A1TSHRKMT2AKDM1A | |
| SCHEMBL108503 | 0.81 | KDM1A (0.39) | ALOX15ALDH1A1TSHRKMT2AKDM1A | |
| SCHEMBL27176381 | 0.81 | KDM1A (0.39) | ALOX15ALDH1A1TSHRKMT2AKDM1A | |
| SCHEMBL11546006 | 0.79 | ALOX15 (0.35) | ALOX15ALDH1A1TSHRKMT2AKDM1A | |
| SCHEMBL11546011 | 0.79 | ALOX15 (0.35) | ALOX15ALDH1A1TSHRKMT2AKDM1A | |
| SCHEMBL9089394 | 0.79 | ALDH1A1 (0.31) | ALOX15ALDH1A1 | |
| SCHEMBL4370364 | 0.78 | ALOX15 (0.32) | ALOX15ALDH1A1 | |
| SCHEMBL30312269 | 0.78 | ALDH1A1 (0.36) | ALOX15ALDH1A1TSHR | |
| SCHEMBL29518711 | 0.78 | ALOX15 (0.32) | ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763015-A1 | SYSTEMATIC MODULAR PRODUCTION OF AMINIMIDE- AND OXAZOLONE- BASED MOLECULES HAVING AT LEAST TWO STRUCTURAL DIVERSITY ELEMENTS | ARQULE, INC. (US) | 1997-03-19 | — | — | EP | claimed |
| WO-1995032184-A1 | SYSTEMATIC MODULAR PRODUCTION OF AMINIMIDE- AND OXAZOLONE- BASED MOLECULES HAVING AT LEAST TWO STRUCTURAL DIVERSITY ELEMENTS | ARQULE, INC. (US) | 1995-11-30 | — | — | WO | claimed |
| US-7034110-B2 | Method of identifying chemical compounds having selected properties for a particular application | ARQULE, INC. (US) | 2006-04-25 | — | — | US | disclosed |
| US-6878557-B1 | Logically ordered arrays of compounds and methods of making and using the same | ARQULE, INC. (US) | 2005-04-12 | — | — | US | disclosed |
| US-20040161610-A1 | Method of identifying chemical compounds having selected properties for a particular application | ARQULE, INC. | 2004-08-19 | — | — | US | disclosed |
| EP-0804726-A4 | A METHOD OF GENERATING A PLURALITY OF CHEMICAL COMPOUNDS IN A SPATIALLY ARRANGED ARRAY | ARQULE INC (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6693168-B1 | CATALYSTS FOR PREPARING CHIRAL AMINO ACIDS | THE TRUSTEES OF BOSTON COLLEGE | 2004-02-17 | — | — | US | disclosed |
| EP-0975584-B1 | SYNTHESIS AND USE OF ALPHA-KETOAMIDE DERIVATIVES AND ARRAYS | ARQULE INC (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6452050-B1 | MONOACYLATION OF SUCH AS 4-AMINOBENZYLAMINE WITH METHYL-2-(2-BENZOTHIENYL)-2-OXOETHANOATE TO PRODUCE POTENTIAL INHIBITORS OF PROTEOLYTIC ENZYMES, PARTICULARLY CYSTEINE PROTEASES | ARQULE, INC. | 2002-09-17 | — | — | US | disclosed |
| US-6358750-B1 | FOR COMBINATORIAL LIBRARIES; DRUG SCREENING | ARQULE, INC. | 2002-03-19 | — | — | US | disclosed |
| EP-1125937-A2 | Spiro [Pyrrolidine-2,3'-oxindole] compounds and methods of use | ARQULE, INC. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0115954-B1 | BICYCLOOCTANE DERIVATIVES AND THEIR PRODUCTION AND USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1987-08-19 | — | — | EP | disclosed |
| US-4680307-A | Carbacyclin analogs | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1987-07-14 | — | — | US | disclosed |
| EP-0207598-A2 | Prostaglandin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |
| EP-0183177-A1 | Unsaturated fatty acid derivatives and their production | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1986-06-04 | — | — | EP | disclosed |
| EP-0139515-A2 | Novel bicyclooctane compounds and production thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-05-02 | — | — | EP | disclosed |
| EP-0136779-A1 | New carbacyclin derivatives, processes for their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-04-10 | — | — | EP | disclosed |
| US-4496745-A | Epoxycarbacyclin derivatives, their preparation and use | SANKYO COMPANY, LIMITED (JP) | 1985-01-29 | — | — | US | disclosed |
| EP-0115954-A2 | Bicyclooctane derivatives and their production and use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-08-15 | — | — | EP | disclosed |
| US-4322435-A | FOR THROMBOSIS | SANKYO COMPANY LIMITED (JP) | 1982-03-30 | — | — | US | disclosed |