SCHEMBL5855341

SCHEMBL5855341

COc1cc2c(cc1OC)CC[CH]C2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.50
CYP3A4 P08684 1/20 0.50
MAOA P21397 6/20 0.46
KDM4E B2RXH2 5/20 0.46
CHRNA7 P36544 2/20 0.46
MAOB P27338 2/20 0.46
SLC6A4 P31645 1/20 0.46
ALDH1A1 P00352 3/20 0.43
GAA P10253 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.41
PDE4D Q08499 1/20 0.41
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40
CA7 P43166 1/20 0.40
DRD1 P21728 1/20 0.40
DRD4 P21917 1/20 0.40
DRD5 P21918 1/20 0.40
ABCB1 P08183 1/20 0.39
GLA P06280 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1787546 0.84 MAPT (0.62) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL2594537 0.78 MAPT (0.68) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL29924708 0.78 MAPT (0.68) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL14481557 0.78 MAPT (0.68) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL5045112 0.74 MAPT (0.62) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL59900 0.74 MAPT (0.62) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL350427 0.74 DRD1 (0.51) MAOACHRNA7MAOBDRD1DRD4
SCHEMBL13456132 0.72 MAPT (0.84) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL6904036 0.72 MAPT (0.84) MAPTCYP3A4MAOAKDM4ECHRNA7
SCHEMBL9781956 0.71 CYP3A4 (0.42) MAPTCYP3A4MAOAKDM4ECHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7122547-B1 Anthranilic acid amides and the use thereof as medicaments SCHERING AG (DE) 2006-10-17 US claimed
EP-1129074-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-05 EP claimed
WO-2000027819-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2000-05-18 WO claimed
US-7122547-B1 Anthranilic acid amides and the use thereof as medicaments SCHERING AG (DE) 2006-10-17 US disclosed
EP-1129074-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2001-09-05 EP disclosed
WO-2000027819-A2 ANTRHRANILIC ACID AMIDES AND THE USE THEREOF AS MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2000-05-18 WO disclosed