Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA6 | P23280 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1638088 | 0.81 | PARP1 (0.48) | TSHRMAPTALDH1A1POLBL3MBTL1 | |
| SCHEMBL561510 | 0.81 | NPC1 (0.38) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2922626 | 0.80 | L3MBTL1 (0.55) | SRD5A2MAPTCA1CA2ALDH1A1 | |
| SCHEMBL11816303 | 0.76 | ATM (0.41) | TSHRMAPTALDH1A1KDM4EGAA | |
| SCHEMBL871977 | 0.76 | CA1 (0.47) | TSHRALOX15MAPTCA12CA1 | |
| SCHEMBL1637722 | 0.76 | HDAC8 (0.46) | TSHRALOX15CA2ALDH1A1KDM4E | |
| SCHEMBL1637852 | 0.76 | ALDH1A1 (0.40) | ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5857066 | 0.76 | KDM4E (0.42) | TSHRSRD5A2MAPTCA12CA1 | |
| SCHEMBL490251 | 0.76 | KDM4E (0.42) | TSHRSRD5A2MAPTCA12CA1 | |
| SCHEMBL2467941 | 0.76 | CA12 (0.46) | TSHRSRD5A2MAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2479165-B1 | GLYCINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-10-25 | — | — | EP | claimed |
| US-9139546-B2 | Tri-aryl/heteroaromatic cannabinoids and use thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2015-09-22 | — | — | US | claimed |
| US-8802679-B2 | Glycine compound | ASTELLAS PHARMA INC. (JP) | 2014-08-12 | — | — | US | claimed |
| CN-102827091-A | Triazine mercapto derivate as well as preparation method and application thereof | UNIV SHANDONG | 2012-12-19 | — | — | CN | claimed |
| EP-2479165-A1 | GLYCINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-07-25 | — | — | EP | claimed |
| US-20120184520-A1 | GLYCINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-07-19 | — | — | US | claimed |
| CN-102516244-A | Hexa-atomic aromatic heterocyclic imidazole mercapto-acetamide derivative, and preparation method and application thereof | UNIV SHANDONG | 2012-06-27 | — | — | CN | claimed |
| CN-102498091-A | Glycine compound | ASTELLAS PHARMA INC | 2012-06-13 | — | — | CN | claimed |
| CN-102276535-A | Azazine mercaptoacetamide derivative and preparation method and application thereof | — | 2011-12-14 | — | — | CN | claimed |
| US-20110207748-A1 | Tri-Aryl/Heteroaromatic Cannabinoids and Use Thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2011-08-25 | — | — | US | claimed |
| US-7888365-B2 | Tri-aryl/heteroaromatic cannabinoids and use thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2011-02-15 | — | — | US | claimed |
| CN-101772491-A | Repaglinide substantially free of dimer impurity | ACTAVIS GROUP PTC EHF | 2010-07-07 | — | — | CN | claimed |
| CN-101631781-A | Improved preparation method of ethyl (S) -2-ethoxy-4- [ N- [ 1- (2-piperidinophenyl) -3-methyl-1-butyl ] aminocarbonylmethyl ] benzoate and application thereof in preparation of repaglinide | ACTAVIS GROUP PTC EHF | 2010-01-20 | — | — | CN | claimed |
| EP-2131655-A2 | TRI-ARYL/HETEROAROMATIC CANNABINOIDS AND USE THEREOF | The University of Tennessee Research Foundation (US) | 2009-12-16 | — | — | EP | claimed |
| US-20080234293-A1 | Tri-aryl/heteroaromatic cannabinoids and use thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2008-09-25 | — | — | US | claimed |
| WO-2008109027-A2 | TRI-ARYL/HETEROAROAROMATIC CANNABINOIDS AND USE THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, THE (US) | 2008-09-12 | — | — | WO | claimed |
| US-20070249620-A1 | Urea Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-10-25 | — | — | US | claimed |
| EP-1764360-A1 | UREA DERIVATIVE | Sankyo Company, Limited (JP) | 2007-03-21 | — | — | EP | claimed |
| US-7094792-B2 | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | BIOVITRUM AB (SE) | 2006-08-22 | — | — | US | claimed |
| EP-0031708-B1 | CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES THEREFOR | ICI PHARMA (FR) | 1984-06-13 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184520-A1 | GLYCINE COMPOUND | SLC5A1, AQP1, VAPB | TSHR 4678/4885ALOX15 1096/4885TPMT 2462/4885 |
| US-20080234293-A1 | Tri-aryl/heteroaromatic cannabinoids and use thereof | CNR1, CNR2, OPRM1 | TSHR 373/4885ALOX15 826/4885TPMT 2156/4885 |
| US-20070249620-A1 | Urea Derivative | UGP2, SLC14A1, DGAT1 | TSHR 1728/4885ALOX15 3710/4885TPMT 308/4885 |
| US-20110207748-A1 | Tri-Aryl/Heteroaromatic Cannabinoids and Use Thereof | CNR1, CNR2, OPRM1 | TSHR 373/4885ALOX15 826/4885TPMT 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.