Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4353124 | 0.98 | DHFR (0.51) | DHFR | |
| SCHEMBL27942592 | 0.85 | DHFR (0.49) | DHFR | |
| Bromide SCHEMBL10829056 | 0.83 | TLR8 (0.36) | DHFR | |
| SCHEMBL4420382 | 0.82 | DHFR (0.53) | DHFR | |
| SCHEMBL8183483 | 0.81 | TLR8 (0.36) | DHFR | |
| SCHEMBL15075218 | 0.81 | DHFR (0.52) | DHFR | |
| SCHEMBL27809370 | 0.81 | DHFR (0.51) | DHFR | |
| SCHEMBL8387208 | 0.78 | DHFR (0.60) | DHFR | |
| SCHEMBL15075239 | 0.78 | DHFR (0.50) | DHFR | |
| SCHEMBL5355383 | 0.78 | DHFR (0.60) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056911-B1 | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof | DANA-FARBER CANCER INSTITUTE (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1154997-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF | DANA FARBER CANCER INST INC (US) | 2002-11-04 | — | — | EP | disclosed |
| EP-1154997-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000059884-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2000-10-12 | — | — | WO | disclosed |