Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10479144 | 0.88 | TLR8 (0.53) | DHFR | |
| SCHEMBL5398097 | 0.88 | TLR8 (0.53) | DHFR | |
| SCHEMBL15075218 | 0.86 | DHFR (0.52) | DHFR | |
| SCHEMBL16984540 | 0.84 | CNR1 (0.42) | DHFR | |
| SCHEMBL27942592 | 0.83 | DHFR (0.49) | DHFR | |
| SCHEMBL8387208 | 0.83 | DHFR (0.60) | DHFR | |
| SCHEMBL16980940 | 0.83 | DHFR (0.47) | DHFR | |
| SCHEMBL16980937 | 0.82 | DHFR (0.49) | DHFR | |
| SCHEMBL4420382 | 0.81 | DHFR (0.53) | DHFR | |
| SCHEMBL4353124 | 0.79 | DHFR (0.51) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797417-B1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIV DUESSELDORF (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-20150216167-A1 | SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES | HEINRICH HEINE UNIVERSITAT DUSSELDORF (DE) | 2015-08-06 | — | — | US | disclosed |
| WO-2013093007-A1 | SELECTIVE INHIBITION OF PHOSPHOENOLPYRUVATE CARBOXYLASES OF C4 PLANTS | HEINRICH HEINE UNIVERSITÄT DÜSSELDORF (DE) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216167-A1 | SELECTIVE INHIBITION OF C4-PEP CARBOXYLASES | CBR3, GRHPR, PCK1 | DHFR 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.