Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30947426 | 1.00 | DHFR (0.48) | DHFR | |
| SCHEMBL5861630 | 0.84 | DHFR (0.47) | DHFR | |
| SCHEMBL5860519 | 0.84 | — | — | |
| SCHEMBL30854161 | 0.84 | DHFR (0.47) | DHFR | |
| SCHEMBL5860738 | 0.84 | DHFR (0.47) | DHFR | |
| SCHEMBL5860792 | 0.80 | DHFR (0.53) | DHFR | |
| SCHEMBL7490302 | 0.79 | DHFR (0.43) | DHFR | |
| SCHEMBL5861757 | 0.77 | DHFR (0.49) | DHFR | |
| SCHEMBL5860472 | 0.74 | DHFR (0.56) | DHFR | |
| SCHEMBL5861648 | 0.71 | DHFR (0.57) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056911-B1 | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof | DANA-FARBER CANCER INSTITUTE (US) | 2006-06-06 | — | — | US | claimed |
| US-7056911-B1 | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof | DANA-FARBER CANCER INSTITUTE (US) | 2006-06-06 | — | — | US | disclosed |