Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7490568 | 0.82 | DHFR (0.41) | DHFR | |
| SCHEMBL30947426 | 0.79 | DHFR (0.48) | DHFR | |
| SCHEMBL5860734 | 0.79 | DHFR (0.48) | DHFR | |
| SCHEMBL5861630 | 0.71 | DHFR (0.47) | DHFR | |
| SCHEMBL5860519 | 0.71 | — | — | |
| SCHEMBL5860738 | 0.71 | DHFR (0.47) | DHFR | |
| SCHEMBL30854161 | 0.71 | DHFR (0.47) | DHFR | |
| SCHEMBL5860472 | 0.69 | DHFR (0.56) | DHFR | |
| SCHEMBL5861648 | 0.66 | DHFR (0.57) | DHFR | |
| SCHEMBL13181216 | 0.66 | DHFR (0.46) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541144-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1154997-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF | DANA FARBER CANCER INST INC (US) | 2002-11-04 | — | — | EP | claimed |
| EP-1154997-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2001-11-21 | — | — | EP | claimed |
| WO-2000059884-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2000-10-12 | — | — | WO | claimed |