Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5861809 | 0.74 | PRKD3 (0.33) | PRKD3CSF1RRETFGFR1FLT1 | |
| SCHEMBL5861834 | 0.74 | DHFR (0.46) | DHFRKDR | |
| SCHEMBL5860256 | 0.73 | MEN1 (0.37) | DHFR | |
| SCHEMBL5860520 | 0.70 | DHFR (0.39) | DHFRPRKD3CSF1RRETFGFR1 | |
| SCHEMBL12683113 | 0.65 | CYP19A1 (0.53) | CYP19A1CYP1A2CYP2C19 | |
| SCHEMBL5861671 | 0.65 | CYP19A1 (0.50) | CYP19A1DHFR | |
| SCHEMBL5860404 | 0.65 | DHFR (0.55) | DHFR | |
| SCHEMBL5861794 | 0.64 | CYP19A1 (0.44) | CYP19A1CYP1A2CYP2C19 | |
| SCHEMBL14492829 | 0.64 | CYP19A1 (0.61) | CYP19A1CYP1A2CYP2C19 | |
| SCHEMBL25972538 | 0.64 | CYP19A1 (0.52) | CYP19A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056911-B1 | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof | DANA-FARBER CANCER INSTITUTE (US) | 2006-06-06 | — | — | US | disclosed |