Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5861793 | 0.74 | SLC2A1 (0.38) | DHFRKDR | |
| SCHEMBL13833595 | 0.74 | DHFR (0.46) | DHFREGFRKDR | |
| SCHEMBL5860427 | 0.73 | DHFR (0.43) | DHFREGFRKDR | |
| SCHEMBL13833594 | 0.72 | DHFR (0.47) | DHFREGFRKDR | |
| SCHEMBL6307851 | 0.71 | DHFR (0.57) | DHFR | |
| SCHEMBL2915133 | 0.70 | DHFR (0.46) | DHFREGFRKDR | |
| SCHEMBL6310645 | 0.70 | DHFR (0.47) | DHFREGFRKDR | |
| SCHEMBL5861670 | 0.70 | — | — | |
| SCHEMBL4871146 | 0.69 | DHFR (0.47) | DHFREGFRKDR | |
| SCHEMBL6390073 | 0.68 | DHFR (0.51) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7056911-B1 | Dibenz[B,F]azepine compounds, pharmaceutical compositions comprising same and methods of use thereof | DANA-FARBER CANCER INSTITUTE (US) | 2006-06-06 | — | — | US | disclosed |