Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL804146 | 1.00 | DPP4 (0.54) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL16967371 | 1.00 | DPP4 (0.54) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL3886489 | 1.00 | DPP4 (0.54) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL804233 | 1.00 | DPP4 (0.54) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL4674647 | 1.00 | DPP4 (0.54) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL7415779 | 1.00 | DPP4 (0.54) | DPP4LMNAADRA2AADRA2CHIF1A | |
| Hydrochloric Acid SCHEMBL5860905 | 0.98 | DPP4 (0.52) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL7710838 | 0.85 | DPP4 (0.52) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL4676515 | 0.85 | ALOX5 (0.53) | DPP4LMNAADRA2AADRA2CHIF1A | |
| SCHEMBL25178201 | 0.83 | ESR1 (0.46) | LMNAHIF1AKDM4ECYP2D6SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041667-B1 | CCR5 modulators | PFIZER, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1013276-A1 | Aminoazacycloalkanes as CCR5 modulators | PFIZER INC. (US) | 2000-06-28 | — | — | EP | disclosed |