Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465621 | 0.90 | MAOB (0.46) | GSK3BBACE1MAOBMAPK14PTGER1 | |
| SCHEMBL4465611 | 0.90 | MAOB (0.46) | GSK3BBACE1MAOBMAPK14PTGER1 | |
| SCHEMBL4386822 | 0.82 | MAOB (0.48) | GSK3BBACE1MAOBMAPK14 | |
| SCHEMBL13603054 | 0.82 | MAPK14 (0.61) | MAPK14 | |
| SCHEMBL5862284 | 0.81 | MAOB (0.48) | GSK3BBACE1MAOBMAPK14PTGER1 | |
| SCHEMBL6526149 | 0.76 | MAOB (0.53) | GSK3BBACE1MAOBMAPK14 | |
| SCHEMBL4384621 | 0.76 | MAOB (0.45) | MAOBMAPK14 | |
| SCHEMBL4378569 | 0.75 | MAPK14 (0.53) | MAOBMAPK14 | |
| SCHEMBL4380109 | 0.74 | MAPK14 (0.47) | GSK3BBACE1MAOBMAPK14PTGER1 | |
| SCHEMBL13602834 | 0.73 | MAPK14 (0.55) | MAOBMAPK14PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067540-B2 | Substituted pyridinones | PHARMACIA CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | GSK3B 1243/4885BACE1 3100/4885MAOB 560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.