Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HPGDS | O60760 | 2/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8770431 | 0.88 | HDAC8 (0.81) | MEN1KMT2AHDAC8HDAC6MAPT | |
| SCHEMBL21295393 | 0.85 | MAPT (0.64) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL2565238 | 0.85 | HDAC8 (0.76) | MEN1KMT2AHDAC8HDAC6MAPT | |
| SCHEMBL4252909 | 0.85 | HDAC8 (0.76) | MEN1KMT2AHDAC8HDAC6MAPT | |
| SCHEMBL5863233 | 0.83 | HDAC8 (0.62) | MEN1KMT2AHDAC8HDAC6MAPT | |
| SCHEMBL13610006 | 0.82 | HPGDS (0.85) | MEN1KMT2AHDAC8HDAC6MAPT | |
| SCHEMBL21254538 | 0.82 | MAPT (0.74) | MEN1KMT2AHDAC8HDAC6MAPT | |
| SCHEMBL14982100 | 0.81 | MEN1 (0.58) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL1663346 | 0.81 | HDAC8 (0.70) | MEN1KMT2AHDAC8HDAC6MAPT | |
| SCHEMBL6014834 | 0.80 | RAB9A (0.67) | MEN1KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125997-B2 | Differential tumor cytotoxicity compounds and compositions | IRM LLC (BM) | 2006-10-24 | — | — | US | claimed |
| US-7125997-B2 | Differential tumor cytotoxicity compounds and compositions | IRM LLC (BM) | 2006-10-24 | — | — | US | disclosed |
| US-20040132786-A1 | Differential tumor cytotoxicity compounds and compositions | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132786-A1 | Differential tumor cytotoxicity compounds and compositions | MIF, FOXM1, MYADM | MEN1 1175/4885KMT2A 4187/4885HDAC8 2867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.