Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5863058 | 0.93 | ROCK2 (0.48) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| Oxalic Acid SCHEMBL5863295 | 0.92 | FYN (0.47) | ALOX5LMNASMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5863069 | 0.91 | ROCK2 (0.49) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5863380 | 0.89 | ROCK2 (0.50) | ALDH1A1ALOX5LMNASMN1; SMN2NPC1 | |
| SCHEMBL5863110 | 0.89 | FYN (0.48) | ALDH1A1ALOX5LMNASMN1; SMN2NPC1 | |
| Oxalic Acid SCHEMBL5863493 | 0.87 | KDM4E (0.45) | ALDH1A1ALOX5LMNASMN1; SMN2NPC1 | |
| Oxalic Acid SCHEMBL5863123 | 0.86 | CYP3A4 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| Oxalic Acid SCHEMBL5863207 | 0.86 | FYN (0.49) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| Oxalic Acid SCHEMBL5863422 | 0.85 | CYP3A4 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| Oxalic Acid SCHEMBL5863223 | 0.85 | KDR (0.47) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132456-B2 | MCH receptor antagonists | ELI LILLY AND COMPANY (US) | 2006-11-07 | — | — | US | disclosed |
| US-20060052449-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052449-A1 | Novel mch receptor antagonists | MCHR1, MCHR2, MC1R | ALDH1A1 1500/4885ALOX5 3485/4885LMNA 3678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.