Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5863123 | 0.93 | CYP3A4 (0.51) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| Oxalic Acid SCHEMBL5863422 | 0.92 | CYP3A4 (0.51) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5863110 | 0.91 | FYN (0.48) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| Oxalic Acid SCHEMBL5863159 | 0.89 | ALDH1A1 (0.51) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| Oxalic Acid SCHEMBL5863295 | 0.89 | FYN (0.47) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| Oxalic Acid SCHEMBL5863234 | 0.86 | SIGMAR1 (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5863289 | 0.85 | FYN (0.50) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL5863297 | 0.85 | KDM4E (0.41) | ALDH1A1KMT2AMCHR1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL5863069 | 0.85 | ROCK2 (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 | |
| Oxalic Acid SCHEMBL5863207 | 0.84 | FYN (0.49) | ROCK2ROCK1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132456-B2 | MCH receptor antagonists | ELI LILLY AND COMPANY (US) | 2006-11-07 | — | — | US | disclosed |
| US-20060052449-A1 | Novel mch receptor antagonists | ELI LILLY AND COMPANY | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052449-A1 | Novel mch receptor antagonists | MCHR1, MCHR2, MC1R | ROCK2 863/4885ROCK1 793/4885CYP3A4 3461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.