Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863768 | 0.84 | ESR1 (0.60) | ESR1CNR1CNR2NR1I2NR3C1 | |
| SCHEMBL5864277 | 0.78 | ESR1 (0.53) | ESR1CNR1CNR2NR1I2HPGD | |
| SCHEMBL5863831 | 0.77 | ESR1 (0.63) | ESR1CNR1CNR2NR1I2NR3C1 | |
| SCHEMBL5864295 | 0.77 | ESR1 (0.58) | ESR1CNR1CNR2NR1I2NR3C1 | |
| SCHEMBL5864160 | 0.77 | ESR1 (0.56) | ESR1CNR1CNR2NR1I2HPGD | |
| SCHEMBL5863848 | 0.76 | CCR3 (0.53) | ESR1OPRM1 | |
| SCHEMBL5863975 | 0.76 | ESR1 (0.55) | ESR1CNR1CNR2NR1I2KMT2A | |
| SCHEMBL5864272 | 0.76 | ESR1 (0.52) | ESR1CNR1CNR2NR1I2KMT2A | |
| SCHEMBL6295367 | 0.75 | ESR1 (0.88) | ESR1CNR1CNR2NR1I2KMT2A | |
| SCHEMBL5863792 | 0.74 | ESR1 (0.53) | ESR1CNR1CNR2NR1I2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053212-B2 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | ESR1 4/4885OPRM1 1264/4885OPRK1 1030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.