Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 12/20 | 0.38 |
| ▸ | PDE1A | P54750 | 4/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864833 | 0.88 | SLC16A1 (0.39) | SMN1; SMN2SLC16A1PDE1APDE1BPDE1C | |
| SCHEMBL5864781 | 0.88 | SLC16A1 (0.47) | SMN1; SMN2SLC16A1PDE1APDE1BPDE1C | |
| SCHEMBL5865248 | 0.86 | PDE1A (0.41) | SMN1; SMN2ALDH1A1SLC16A1PDE1APDE1B | |
| SCHEMBL5864884 | 0.83 | SLC16A1 (0.49) | SMN1; SMN2ALDH1A1KMT2ASLC16A1PDE1A | |
| SCHEMBL7007349 | 0.82 | PDE1A (0.38) | SMN1; SMN2ALDH1A1SLC16A1PDE1APDE1B | |
| SCHEMBL7006816 | 0.81 | SLC16A1 (0.42) | SMN1; SMN2ALDH1A1SLC16A1PDE1APDE1B | |
| SCHEMBL7004534 | 0.81 | PDE1A (0.41) | ALDH1A1SLC16A1PDE1APDE1BPDE1C | |
| SCHEMBL8141177 | 0.80 | SLC16A1 (0.39) | SMN1; SMN2ALDH1A1SLC16A1PDE1APDE1B | |
| SCHEMBL7006740 | 0.80 | PDE1A (0.38) | SMN1; SMN2ALDH1A1KMT2ASLC16A1PDE1A | |
| SCHEMBL5864724 | 0.79 | LMNA (0.42) | SMN1; SMN2ALDH1A1KMT2ASLC16A1PDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984644-B2 | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | claimed |
| US-6469014-B1 | IMMUNOSUPPRESSIVE ACTIVITY | ASTRAZENECA AB (SE) | 2002-10-22 | — | — | US | claimed |
| EP-0991653-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-10-16 | — | — | EP | claimed |
| US-6984644-B2 | Treatment of skin disorders using thieno[2,3-D]pyrimidinediones | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | disclosed |
| US-6469014-B1 | IMMUNOSUPPRESSIVE ACTIVITY | ASTRAZENECA AB (SE) | 2002-10-22 | — | — | US | disclosed |