Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 4/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | GPR3 | P46089 | 4/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581309 | 0.92 | CXCR2 (0.43) | CXCR2LIPEPDE2AGPR3GRM2 | |
| SCHEMBL30376702 | 0.92 | CXCR2 (0.43) | CXCR2LIPEPDE2AGPR3GRM2 | |
| SCHEMBL14874698 | 0.85 | SNCA (0.37) | LPLLIPGCA1CA2CA9 | |
| SCHEMBL17129378 | 0.79 | AR (0.42) | CXCR2LIPEALDH1A1 | |
| SCHEMBL30377217 | 0.78 | GPR3 (0.46) | PDE2AGPR3ALDH1A1POLBGAA | |
| SCHEMBL518353 | 0.78 | GPR3 (0.46) | PDE2AGPR3ALDH1A1POLBGAA | |
| SCHEMBL15572934 | 0.78 | PTGS1 (0.38) | — | |
| SCHEMBL15573245 | 0.78 | ALK (0.32) | — | |
| SCHEMBL20191122 | 0.78 | CXCR2 (0.41) | CXCR2LIPEGPR3CA1CA2 | |
| SCHEMBL28961843 | 0.77 | CXCR2 (0.42) | CXCR2LIPEGPR3CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |