Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.47 |
| ▸ | BCL2A1 | Q16548 | 4/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.39 |
| ▸ | HK1 | P19367 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866204 | 1.00 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MCL1BCL2A1HTR6 | |
| Hydrochloric Acid SCHEMBL5866348 | 0.99 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MCL1BCL2A1HTR6 | |
| SCHEMBL5866187 | 0.89 | MCL1 (0.44) | ALDH1A1SMN1; SMN2MCL1BCL2A1HTR6 | |
| SCHEMBL5866190 | 0.89 | MCL1 (0.44) | ALDH1A1SMN1; SMN2MCL1BCL2A1HTR6 | |
| SCHEMBL5866428 | 0.87 | MCL1 (0.41) | ALDH1A1SMN1; SMN2MCL1BCL2A1CA12 | |
| SCHEMBL5866424 | 0.87 | MCL1 (0.41) | ALDH1A1SMN1; SMN2MCL1BCL2A1CA12 | |
| SCHEMBL5866284 | 0.84 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2CA12CA9GAA | |
| SCHEMBL5866278 | 0.84 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2CA12CA9GAA | |
| SCHEMBL5866205 | 0.83 | GUSB (0.55) | ALDH1A1SMN1; SMN2MCL1BCL2A1CCR2 | |
| SCHEMBL5866211 | 0.83 | GUSB (0.55) | ALDH1A1SMN1; SMN2MCL1BCL2A1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074820-B2 | Amidino derivatives and their use as thrombin inhibitors | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | claimed |
| EP-0917528-B1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-18 | — | — | EP | claimed |
| US-20020040043-A1 | Amidino derivatives and their use as thrombin inhibitors | ANTONSSON THOMAS (SE) | 2002-04-04 | — | — | US | claimed |
| US-6221898-B1 | ANTICOAGULANTS | ASTRA AKTIEBOLAG (SE) | 2001-04-24 | — | — | US | claimed |
| EP-0917528-B1 | NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040043-A1 | Amidino derivatives and their use as thrombin inhibitors | SERPINC1, F2, SERPINE1 | ALDH1A1 4316/4885SMN1; SMN2 4046/4885MCL1 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.