Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13094499 | 0.95 | SMN1; SMN2 (0.43) | SMN1; SMN2OPRK1ALDH1A1POLBHCRTR2 | |
| SCHEMBL582094 | 0.95 | HCRTR2 (0.38) | SMN1; SMN2HCRTR2BRD4CREBBP | |
| SCHEMBL587882 | 0.82 | HCRTR2 (0.36) | HCRTR2 | |
| SCHEMBL586999 | 0.82 | OPRK1 (0.35) | SMN1; SMN2OPRK1ALDH1A1POLBHCRTR2 | |
| SCHEMBL581200 | 0.79 | HCRTR2 (0.36) | ALDH1A1POLBHCRTR2 | |
| SCHEMBL586824 | 0.79 | HCRTR2 (0.36) | ALDH1A1POLBHCRTR2 | |
| SCHEMBL581381 | 0.79 | HCRTR2 (0.36) | ALDH1A1POLBHCRTR2 | |
| SCHEMBL581808 | 0.78 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1POLBMAPTHSD17B10 | |
| SCHEMBL582187 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2OPRK1ALDH1A1POLBMAPT | |
| SCHEMBL581337 | 0.73 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1POLBHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |