Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 5/20 | 0.53 |
| ▸ | MMP7 | P09237 | 4/20 | 0.53 |
| ▸ | MMP12 | P39900 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 13/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.48 |
| ▸ | ADAMTS1 | Q9UHI8 | 2/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598118 | 0.83 | ADAM17 (0.63) | MMP3MMP7MMP13MMP2ADAM17 | |
| Trifluoroacetic Acid SCHEMBL5866692 | 0.82 | MMP3 (0.74) | MMP3MMP7MMP12MMP13MMP2 | |
| SCHEMBL6600912 | 0.82 | ADAM17 (0.61) | MMP3MMP7MMP13MMP2ADAM17 | |
| SCHEMBL6594203 | 0.82 | ADAM17 (0.61) | MMP3MMP7MMP13MMP2ADAM17 | |
| SCHEMBL6594393 | 0.82 | ADAM17 (0.61) | MMP3MMP7MMP13MMP2ADAM17 | |
| SCHEMBL5255328 | 0.80 | MMP3 (0.81) | MMP3MMP7MMP12MMP13MMP2 | |
| SCHEMBL5866655 | 0.78 | ADAM17 (0.46) | MMP3MMP7MMP12MMP13MMP2 | |
| SCHEMBL6596115 | 0.78 | ADAM17 (0.58) | MMP3MMP7MMP13MMP2ADAM17 | |
| SCHEMBL6702199 | 0.78 | ADAM17 (0.58) | MMP3MMP7MMP13MMP2ADAM17 | |
| SCHEMBL6599283 | 0.78 | ADAM17 (0.58) | MMP3MMP7MMP13MMP2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074810-B2 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-11 | — | — | US | disclosed |
| US-20040116491-A1 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-17 | — | — | US | disclosed |