Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5866929 | 0.82 | CRHR1 (0.32) | CRHR1TDP1TSHR | |
| SCHEMBL7625265 | 0.67 | CRHR1 (0.36) | CRHR1MEN1KMT2ATSHR | |
| SCHEMBL7626686 | 0.66 | CDK1 (0.34) | CRHR1TDP1 | |
| SCHEMBL7216710 | 0.62 | PDK2 (0.33) | PDK2CRHR1 | |
| SCHEMBL13170602 | 0.61 | — | — | |
| SCHEMBL12495762 | 0.61 | PDK2 (0.42) | PDK2MEN1KMT2ATSHR | |
| SCHEMBL6092339 | 0.61 | CRHR1 (0.57) | CRHR1TDP1 | |
| SCHEMBL7540765 | 0.59 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL1762903 | 0.59 | CRHR1 (0.46) | CRHR1TDP1 | |
| SCHEMBL5844067 | 0.57 | PDK2 (0.37) | PDK2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992188-B1 | Substituted heterocyclic derivatives | PFIZER, INC. (US) | 2006-01-31 | — | — | US | disclosed |
| EP-0778277-B1 | Substituted heterocyclic derivatives as CRF antagonists | PFIZER (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-0778277-A1 | Substituted heterocyclic derivatives as CRF antagonists | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |