Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.36 |
| ▸ | FLT1 | P17948 | 6/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCND3 | P30281 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542095 | 0.91 | FGFR1 (0.34) | ABL1FGFR1FLT1FLT3PDPK1 | |
| SCHEMBL3595759 | 0.90 | FGFR1 (0.38) | ABL1FGFR1FLT1FLT3PDPK1 | |
| SCHEMBL5866756 | 0.87 | FGFR1 (0.35) | ABL1FGFR1FLT1FLT3PDPK1 | |
| SCHEMBL3539088 | 0.85 | FGFR1 (0.39) | ABL1FGFR1FLT1CDK4CCNA2 | |
| SCHEMBL5866691 | 0.84 | FGFR1 (0.40) | ABL1FGFR1FLT1CDK2FLT3 | |
| SCHEMBL3538825 | 0.82 | FOXO1 (0.39) | ABL1FGFR1FLT1CDK4CCNA2 | |
| SCHEMBL3532400 | 0.81 | FGFR1 (0.54) | ABL1FGFR1FLT1CDK2FLT3 | |
| SCHEMBL3536935 | 0.81 | FGFR1 (0.39) | ABL1FGFR1FLT1FLT3PDPK1 | |
| SCHEMBL3535802 | 0.81 | FGFR1 (0.37) | ABL1FGFR1FLT1FLT3PDPK1 | |
| SCHEMBL6582455 | 0.81 | ABL1 (0.53) | ABL1FGFR1FLT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7064215-B2 | Indazole benzimidazole compounds | CHIRON CORPORATION (US) | 2006-06-20 | — | — | US | disclosed |